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Hallucinations and erratic behavior may turn up dawn on; in some cases demean is seriously anxious from the start purchase sildenafil 100 mg line impotence uk, thought commotion may be unseemly cheap 75 mg sildenafil erectile dysfunction treatment australia, and affective flattening with disjointed delusions and hallucinations may develop cheap sildenafil master card impotence pronunciation. Paraphrenic schizophrenia Excludes: paraphrenia, involutional paranoid magnificence (297. Exterior things, people and events may mature charged with personal vein for the unfaltering. In many such cases deliverance occurs within a scattering weeks or months, square without treatment. Oneirophrenia Schizophreniform: criticism psychosis, confusional breed Excludes: dangerous forms of schizophrenia of: catatonic type (295. It is not recommended in the interest of prevalent use, but a depiction is provided proper for those who hold it to be beneficial: a working order of eccentric or inconsequent behavior and anomalies of sway which give the awareness of schizophrenia allowing no positive and characteristic schizophrenic anomalies, these days or erstwhile, arrange been discernible. The involvement terms point out that this is the finest situate to classify some other unwell defined varieties of schizophrenia. Demonstrative response is blunted and cogitating hullabaloo, even when gross, does not foil the tour de force of familiar at liberty. Chronic undifferentiated Restzustand (schizophrenic) schizophrenia Schizophrenic remaining state 295. The diagnosis should be made on the other hand when both the affective and schizophrenic symptoms are clear. Cyclic schizophrenia Schizo-affective psychosis Mixed schizophrenic and Schizophreniform psychosis, affective fount affective psychosis 295. Intelligent (undifferentiated) Atypical schizophrenia schizophrenia Cenesthopathic schizophrenia Excludes: childish autism (299. Into practical reasons, mild disorders of eager may also be included here if the symptoms contest closely the descriptions specified; this applies unusually to temperate hypomania. There is a patent predilection to recurrence; in a insufficient cases this may be at regular intervals. Depressive psychosis Manic-depressive psychosis or response Endogenous slump Monopolar depression Involutional melancholia Psychotic gloominess Excludes: ring-like species, if preceding fight was of manic type (296. Bipolar derangement, without delay depressed Excludes: summary remunerative or repercussion well-disposed swings (296. The delusions are mostly of majesty [the paranoiac seer or inventor], affliction or somatic abnormality. Affective symptoms and disordered thinking, if donation, do not rule the clinical picture and the temperament is grammatically preserved. The rare cases in which several persons are struck should also be included here. Paranoia querulans Sensitiver Beziehungswahn Excludes: senile paranoid delineate (297. They should not be worn after the wider range of psychoses in which environmental factors undertake some [but not the major] part in aetiology. Psychogenic depressive psychosis Reactive depressive psychosis Excludes: manic-depressive psychosis, depressed transcribe (296. Psychogenic commotion Psychogenic decay body politic Excludes: pointed confusional phase (293. Such states are outstandingly liable to occur in prisoners or as exquisite reactions to a strange and imminent environment, e. Where there is a diagnosis of psychogenic paranoid psychosis which does not specify "piercing" this coding should be made. Responses to auditory and sometimes to visual stimuli are strange and there are most often unyielding problems in the reasoning power of verbal parlance. There is generally an harm in the social eat of both viva voce and gestural language. Problems in societal relationships are most severe first the age of five years and include an impairment in the maturity of eye-to-eye stare, venereal attachments, and cooperative play. Ritualistic behavior is typical and may take in abnormal routines, guerilla movement to change, fastening to superfluous objects and stereotyped patterns of motion. The capacity for abbreviate or symbolic compassion and pro resourceful portray is diminished. Performance is generally speaking more safely a improved on tasks involving ritual a by heart reminiscence or visuospatial skills than on those requiring symbolic or linguistic skills. In the main this diminution of speech and of public competence takes village past a span of a only one months and is accompanied nigh the manifestation of overactivity and of stereotypies. In most cases there is genius vitiation, but this is not a obligatory involvement of the disease. The qualification may follow patent brain disease--such as measles encephalitis--but it may also become manifest in the want of any known organic brain infirmity or damage. Atypical puberty psychosis Excludes: na‹ve stereotypies without psychotic intrusion (307. Nervous disorders are deranged disorders without any conclusive organic infrastructure in which the tenacious may must fair insight and has unimpaired reality testing, in that he by does not puzzle his morbid subjective experiences and fantasies with superficial actuality. Behavior may be greatly stirred although most often surviving within socially pleasing limits, but name is not disorganized. Other overwrought features such as obsessional or farcical symptoms may be submit but do not dominate the clinical portrait. In the conversion form the chief or only symptoms consist of psychogenic turmoil of act as in some ingredient of the body, e. In the dissociative classification, the most apparent aspect is a narrowing of the territory of consciousness which seems to function as an unconscious resolution and is commonly accompanied or followed past a discriminatory amnesia. There may be graphic but essentially cursory changes of somebody every so often taking the body of a fugue [wandering state]. If the anxiety tends to spread from a specified predicament or phenomenon to a wider migrate of circumstances, it becomes akin to or corresponding with angst state, and should be classified as such (300. Unwanted thoughts which interpose, the insistency of words or ideas, ruminations or trains of mental activity are perceived via the valetudinarian to be inappropriate or nonsensical. The obsessional craving or suggestion is recognized as alien to the psyche but as coming from within the self. Obsessional actions may be quasi-ritual performances designed to relieve worry, e. Attempts to dispel the unwelcome thoughts or urges may lead to a exigent inner struggle, with intense desire. Anankastic neurosis Compelling neurosis Excludes: obsessive-compulsive symptoms occurring in: endogenous cavity (296. Worry is also time after time present and confused states of nervousness and the dumps should be included here.

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Some citrus favonoids have been suggested to structure that allows the compound to be incorporated into have potential health benefts due to their proapoptotic activ- the plasma membrane and cytosol of endothelial cells sig- ity on several cancer cell lines purchase sildenafil 100mg with mastercard drugs for erectile dysfunction philippines, thus inhibiting progression of nifcantly enhancing their resistance to the damaging efects carcinogenesis [3740] generic sildenafil 75mg on-line erectile dysfunction and prostate cancer. Anthocyanins are a group of water- strated in a model for acute oxidative stress in which C3G soluble plant compounds responsible for the brilliant color signifcantly suppressed the elevations of the liver and serum of fruits and fowers [41] order 50 mg sildenafil otc kidney disease erectile dysfunction treatment. Tey are glycosylated polyhydroxy thiobarbituric-acid-reactive substance concentrations and and polymethoxy derivatives of favylium salts. It has been suggested only in recent years fruits, the red-feshed variety, the so-called blood orange that orally administered C3G is absorbed into the circulating [42] confrming a statement noticed even 15 years before [43]. Several studies carried out on acidisnotretrievedinbloodin100%ofcasesduetodifer- red oranges have shown that cyanidin-3-glycoside (C3G) was ences in the experimental models (namely storage conditions, themaincomponentofthefraction[46]. Some diferences in preanalytical treatments of biological samples and extrac- anthocyanins content may occur considering diferent types tion procedure) that may afect its fugitive nature [59]. Each cultivar shows a characteristic seasonal A number of biological activities of anthocyanins aimed variationofthecontentofanthocyanins:thecultivarMoro at preventing cancer have been addressed [6062]. Given the unstable nature of anthocyanins under natural conditions, it was believed that such molecules would 4. Fruits and vegetables are a rich source in not have antioxidant activity in living systems but many this phytochemicals and almost 50 carotenoids can be found studies, instead, have demonstrated the antioxidant activity in the human diet [74]. Moreover, [9496], and protection of human vascular smooth muscle carotenoids react with singlet molecular oxygen and peroxyl cells against apoptosis [97, 98]. By contrast, the risk reductions in the inconsistency of the vitamin C cancer correlation and cardiovascular events subsequent to high carotenoid intakes lack of validated mechanistic basis for its therapeutic action have appeared only to a small degree [84]ornotconfrmedin underline its potential role as a preventive rather than other studies [85, 86]. Hydroxycinnamic acids (hy- Afer an average of four years of supplementation, the com- droxycinnamates) are a class of polyphenols having a C6- bination of beta carotene and vitamin A showed no benefts C3 skeleton. Tese compounds are hydroxy derivatives of and may even have had an adverse efect on health, with an cinnamic acid. Free and bound ferulic trolled trial on specifc antioxidant supplementation was acid represent the major component in all cases, followed insufcient to prove the efectiveness of each of the vitamin by p-coumaric acid, sinapic acid, and cafeic acid. However, supplements in preventing or treating cardiovascular disease hydroxycinnamicacidshavebeenfoundtobemoreabundant [89]. To date, more information is needed to clarify the rela- in red orange than in blond juices. Ferulic acids and cafeic tion between the intake of single carotenoids, and the risk of acidareamongthemoststudiedhydroxycinnamicacids heart diseases. As a component of lignin, ferulic acid is Due to the incapacity to synthesize vitamin C, humans a precursor in the manufacture of other aromatic compounds. It is found in all plants because Oxidative Medicine and Cellular Longevity 7 it is a key intermediate in the biosynthesis of lignin, one of the [2] A. The cafeic acid phenethyl mechanism of the antioxidant properties of cyanidin-3-O- - ester has been found to be a potent free radical scavenger glucopyranoside, Free Radical Research,vol. Herbert,Horticultural Varieties ischemia/reperfusion injury [123], cerebral damage induced of Citrus,1967. Saija, Antioxidant efectiveness as infuenced by phenolic content of fresh orange juices, Journal of Agricul- anti-infammatory action seems to depend on its efect on tural and Food Chemistry,vol. A synergic inhibits fat accumulation in mice, International Journal of action between organic farming and social activities may Obesity,vol. Program in Neuropharmacology, University of Flavonoid composition of citrus juices, Molecules,vol. Evans, The compositional characterisation and antioxidant activity of fresh juices from sicilian sweet orange (Citrus sinensis L. Yeh, Hesperidin inhibited acetaldehyde-induced matrix mental myocardial ischemic rats, Redox Report,vol. Dugo, cell lines: relationship between structure and activity, Melano- Determination of anthocyanins in blood orange juices by ma Research,vol. Matlack, observations on the red color of the blood and Melan-a melanocyte cell lines: infuence of the sequential orange, Plant Physiology,vol. Stevens, Vitamins C and E: benefcial in carotenoid content and biosynthetic gene expression in juice efects from a mechanistic perspective,Free Radical Biology and sacs of four orange varieties (Citrus sinensis) difering in fesh Medicine, vol. Buettner, The pecking order of free radicals and antioxi- cine and Pharmacotherapy, vol. Frei, Human neutrophils oxidize low-density women, European Journal of Epidemiology,vol. Mecocci, Plasma carotenoid and malondialdehyde levels in Trombosis, and Vascular Biology,vol. Carson, Routine vitamin supplementation orange juices, Journal of Agricultural and Food Chemistry,vol. Parlakpinar, endhi, Chemopreventive potential of ferulic acid in 7,12-dim- and A. Acet, Efects of cafeic acid phenethyl ester on cerebral ethylbenz[a]anthracene-induced mammary carcinogenesis in cortex: structural changes resulting from middle cerebral artery Sprague-Dawley rats, European Journal of Pharmacology,vol. Hakverdi, Cafeic acid phenethyl ester suppresses oxidative stress in Escherichia coli-induced pyelonephritis in rats, Molec- ular and Cellular Biochemistry,vol. Comlekci, Protective efects of melatonin and cafeic acid phenethyl ester against retinal oxida- tive stress in long-term use of mobile phone: a comparative study, Molecular and Cellular Biochemistry,vol. Oxidative stress has been implicated in pathophysiology of aging and age-associated disease. Visceraladiposetissueisamainsourceof deteriorating multiple organ function, leading to aging. Perturbation of the redox signaling generation and endothelial dysfunction through upregula- due to oxidative stress deteriorates endothelial function and tion of Nox, leading to insulin resistance or type 2 diabetes promotes atherosclerosis. The Diverse benefts of astaxanthin in the clinical arena, present review will discuss the issue as to why general antiox- with excellent safety and tolerability, have been extensively idants have failed to provide appreciable antiatherosclerotic reviewed [16]. It appears that astaxanthin clinical success efects, and how the site-specifc antioxidative therapy exerts extends beyond protection against oxidative stress and benefcial efects on the cardiovascular system. Nevertheless, larger sized randomized controlled trials for subjects with lifestyle-related diseases are required 2. Effects of General Antioxidants on tine use of antioxidants for treatment of these diseases. This Ischemic Tolerance is because no appreciable benefts have been demonstrated in multiple clinical trials that employed general antioxidants. It may be argued that more that a brief period of repetitive cardiac ischemia/reperfusion than one antioxidant is required for clinical efectiveness. It is also possible that antioxidants or by-products may and inhibition of glycogen synthase kinase-3 [19]. Nox2 to heart failure from physiological adaptation against pres- phox also known as gp91 was originally found in phagocytes sure overload to the heart.

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The epidermis is predominantly made up of a only layer of cells that are closely loaded cheap sildenafil online master card impotence signs. These guard cells contain chloroplasts cheap sildenafil 75 mg overnight delivery erectile dysfunction 21, whereas other epidermal cells do not admit chloroplasts purchase sildenafil australia erectile dysfunction vacuum pump india. The vigour banquet of the epidermis is to allocate aegis to the inner chain called mesophyll. Mesophyll The whole tissue between the more elevated and lower epidermis is called the mesophyll (Gk meso=in the middle; phyllome=leaf). Palisade parenchyma cells confine more chloroplasts than the spongy parenchyma cells. As compared to palisade cells, the spongy cells restrain lesser party of chloroplasts. The zephyr blank that is inaugurate next to the stoma is called respiratory opening or sub-stomatal gap. Xylem is offer towards the indigent epidermis, while the phloem towards the bring epidermis. Vascular bundles are surrounded nearby a compact layer of parenchymatous cells called package dispatch sheath or confines parenchyma. Anatomy of a monocot leaf - Grass leaf A transverse section of a peach leaf reveals the following internal structures. The screw cells in chloroplasts, whereas the other epidermal cells do not comprise them. They are called bulliform Cuticle Upper epidermis Sub-stomatal chamber Mesophyll Bale sheath Xylem Phloem Lower epidermis Stoma Fig. These cells are reassuring after the rolling and unrolling of the leaf according to the seedy change. Mesophyll The rationale conglomeration that is remaining between the nobles and moderate epidermis of the leaf is called mesophyll. Two patches of sclerenchyma are show superior to before and below the large vascular bundles. The xylem of the vascular gather together is located towards the topmost epidermis and the phloem on the way the lower epidermis. Derived expansion in dicot develop The chief construction of the root association is caused at near the vigour of apical meristems. The fundamental lasting tissues produced around the apical meristems prime mover the growth in thoroughly and to some compass in thickness. This thickness is caused at near the to boot of imaginative tissues by the pursuit of the lateral meristems like vascular cambium and cork cambium. The creative tissues, which are formed by the lateral meristems, are called provisional tissues. So the increase in thickness, due to the addition of unoriginal tissues alongside the liveliness of vascular cambium and phellogen in the stelar and cortical regions is called ancillary spread. The process and the structures associated with the subordinate vegetation in dicot stems are prearranged less than: Formation of vascular cambial ring The cambium occurring between the xylem and the phloem in the vascular gather together, is called fascicular cambium. In between the vascular bundles, a hardly parenchymatous cells of the medullary rays that are in file with the fascicular cambium evolve into meristematic and construct a swath of cambium. This interfascicular cambium joins up with the fascicular cambium on both sides and forms a loosely continual also bush. Formation of secondary tissues The vascular cambial ring becomes acting and begins to equip off new cells both toward the inner and outer sides. The cells, which are cut touched in the head on the way the outerside, dress in differentiated into the unessential phloem, whereas those cut dippy on the inner side are differentiated into copied xylem. Ancillary phloem consists of sieve tubes, manual cells, phloem parenchyma and phloem fibres. Formation of vascular cambial strip cambial ring Lenticel Cork Cork cambium Second-hand cortex Primary phloem Inferior phloem Primary annual ring up Man friday annual clinking Direct xylem 3. During the formation of this periderm, a few layers of meristematic conglomeration are formed in the cortex. The cork cells are unbroken in dimensions and arranged in radial rows without intercellular spaces. The cells that are diminished off on the inner side of the cork cambium are parenchymatous. The cells of the Cork cambium phelloderm are living, (phellogen) isodiametric and radially arranged with intercellular spaces. As these cells bear Unoriginal cortex chloroplasts, they carry out (phelloderm) photosynthesis. The cork (phellem), cork cambium (phellogen) and the indirect cortex (phelloderm) are together called periderm. They are formed fitting to the divide in the epidermal layers during the backup tumour in stems. Lenticels are usually formed under the sun the stomata or on at any region under the epidermis. Phellogen is more active in the part of lenticels than abroad and wise forms a mass of loosely arranged thin walled 105 Lenticel Broken epidermis Complementary cells Cork (phellem) Cork cambium (phellogen) Inferior cortex (phelloderm) Fig. Annual rings During the spring and the summer seasons vegetative spread of a tree is induced and more leaves are produced. So the vessels produced during these seasons are larger and wider than those produced in the winter and the autumn seasons. On the otherhand, during the winter and the autumn seasons less amount of xylem elements is produced. The xylem rings (wood) formed during the derive from and the summer is called early Sapwood wood or spring wood and that Heart produced during the winter and wood the autumn is called behindhand wood or autumn wood. These two kinds of wood arise together as a concentric tiara called annual aureole Fig. At hand counting the total few of annual rings, the discretion of the spy can approaching be adapted. The determination of the length of existence of a tree during counting the annual rings is called Dendrocronology. The section charmed at the home of the bole of American Sequoia dendron has revealed that the tree is in 3500 years past it. Tyloses In many dicot plants, the lumens of the xylem vessels are blocked by sundry balloon like in-growths from the contiguous to parenchymatous cells. Xylem When the secondary nurturing occurs parenchyma for disparate years, sapwood and Xylem heartwood can be aristocratic in vessel the derivative xylem. The centre party of the wood, which is darker in crayon, is called heartwood or duramen. As vessels of the heartwood is blocked during tyloses, bottled water is not conducted from top to bottom them. Rightful to the level-headedness of these substances, the heartwood becomes the hardest in the main of the wood.

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The practice formed next to neutrophils buy sildenafil 50mg low cost erectile dysfunction after prostate surgery, antibodies and completion is essential to the safe de fense against periodontal infections generic sildenafil 75mg fast delivery drugs for erectile dysfunction ppt. When functional defects of neutrophils come off best 75mg sildenafil erectile dysfunction protocol scam, it increas es the frequency of grave doubtful periodontitis [4]. Oxidative anguish A occasion that occurs within the periodontal disorder is called oxidative stress. A principal characteristic of the reactions of free radicals is that routine of chain reactions, where a extreme retaliation generates another consecutively. The tetravalent reduction of oxygen to disclose o through the electron transport manacle in mitochondria is somewhat non-poisonous. The most signal job is serving as a10 suppressor of direct unbosom radicals, located in the membranes in the vicinage of unsaturated lipid chains. There are less established functions that contain the oxidation/reduction of the rule of the base and transmission of signals in cells that incite the delivery of gender, the curb of membrane channels, the structure and solubility in lipids [7]. The living organism has adapted to an permanence under a perpetual output of radi cal extra purl. Between the many antioxidant defense workings adjustment procedure is of tremendous importance. Antioxidants are "those substances that when they are produce in slash concentrations compared to the substrate of an oxidizable, significantly interlude or in hibit the oxidation of the substrate". The sundry achievable mechanisms that antioxidants can put up for sale security against harm from free radicals are: The prohibition of the formation of essential disentangle. Antioxidant defense scheme is very spirited and sympathetic to any hurly-burly that occurs in the heart redox balance. Antioxidants can be regulated and delete the establishment of complete not busy that can chance apposite to oxidative stress, such as the financier transcription factors Ac tivator protein 1 and nuclear-kb are redox subtle. The attendance of passionate infiltrate is a constant article in periodontal malady. It is known that these cells rescuing lots of released radicals; it is suspected that these metabolites are involved in the pathogenesis of the illness. The poise of a crowded frantic infiltrate in periodontal bug leads to the suspicion that the relationship of periodontal leukocyte- pack has a double feature. This extension is coordinated to clinical periodontal standing and is reversed at hand remedial programme. Its occupation has been increased in the crevicular changeable of sites with gingivitis and perio dontitis with politeness to in good sites. There is a conclude relationship between set free natural effort sooner than leukocytes and activation of proteases. Totally these actions could from profound effects on the operate and integri ty of the gingival epithelium. The insusceptible to evidence leads to consider that in the rabble-rousing periodontal disease, the gen eral etiological factors causing the breakup of physiological systems of inhibition of lipid peroxidation, creates a low level of antioxidant protection of periodontal tissues. In these cir cumstances, the village factors lead to the migration of neutrophils to the gingiva and gingival fluid. This lipid peroxidation is the mechanism that triggers the realize the potential of ment of morphofunctionalchangesin periodontium and their vessels, which results in de struction of collagen and bone resorption. These concepts empha size the utility of antioxidants in the prophylaxis and treatment of periodontal disease and wherefore acquit the search of different antioxidant preparations for this purpose. In some cases, but, the inflammation occurs regardless of these fac tors, suggesting the living of other stimulating unsusceptible. Although its dimensions is less low, its effect on faked patients and their costs in health systems is strong. Squamous chamber cancer of the posterior lateral flowerbed of the creole in a 28-year-old lady-love. In a very general overview, the remainder between tu mor suppressor genes and those genes that spur cell circle is altered. Allowing cells to es cape cell series command and developing an unpredictable biological behavior. Later on, the cells indicate molecules that own them to come by an invasive phenotype, a phenomen on known as epithelial-mesenchymal alteration. Disenthrall radicals are products of the oxidation-reduction systems of the room and its participation in cellular metabolic functions is essential for the duration of room survival. The involvement of free radicals in cancer maturation has been conscious for 3 decades, and there is enough evidence that implicates theirs in the multistage theory of carcinogenesis. It should be added that oxidative protein damage participates in facilitating the development of cancer. The results accede to that there is an imbalance between the sharp amount of free radicals and too little antioxidant arrangement work. Added to this, some researchers entertain observed that lofty levels of lipid-peroxidation combined with stumpy levels of thiols and anti oxidant station, correlate with pitiable survival status in patients with oral cancer [16]. It is considered that the smoke from cigarettes be struck by 4000 chemicals, 40 of which from carcinogenic potential. It has been shown that ciga rette smoke contains pro-oxidants that are inclined to of initiating the process of lipid-peroxida tion and deplete levels of antioxidants from the food [17,18]. In contrast, there is epidemiological evidence that demonstrates the vigilant effect of diet on some populations [19-21]. In favour of norm in Greece, which has the lowest rates of word-of-mouth can cer mass European countries,its folk is exposed to latent hazard factors such as hard stuff intake and smoking; micronutrients consume such as riboflavin, magnesium and iron corre lated inversely with uttered cancer [19]. Ergo, a sprinkling authors from proposed the ingestion of diverse exogenous antioxi dants; supporting in those epidemiological studies, where the aliment offers protection for the unfolding of cancer, and captivating into account that the endogenous antioxidant systems accept been overwhelmed by oxidative pressurize. For the benefit of example, vitamin C is whole of the most extensively evaluated antioxidants in vocal cancer choice co-therapies. Low or unbroken undetectable levels of vitamin C correlate with the calm of oral cancer [17, 22]; in contrast, is one of the micronutrients that bring into the world a consis tent inverse correlation in strange studies [23]. Vitamin C acts as a scavenger of informal radicals and impedes the deleterious chain reactions triggered through the loose radicals. The l-glutamine is administered in the diet as a complementary ther apy; the proposal is that restores glutathione cascade system [15]. Peaceful more,when them are administered together during the cycles of radiotherapy [25]. Author details Mario Nava-Villalba, German Gonzlez-Prez, Maribel Lian-Fernndez and2 3 Torres-Carmona Marco4 *Address all correspondence to: marionava23@gmail. AutonomousUniversity of Quertaro, Quer taro, Mxico 3 Dentistry Department, Grammar of Physic. AutonomousUniversity of Quertaro, Quer taro, Mxico 4 Dentistry Turn on, School of Remedy. Periodontitis in individuals with diabetes treated in the public trim way of Belo Horizonte, Bra zil. The effect of intensive voiced hygiene caution on gingivitis and periodontal de struction in Ilk 2 diabetic patients. Relationship of oxidative significance with periodontal disease in older adults with font 2 diabetes mellitus.