Date Funded: 2/09

Dr. Steve Ellis, PhD, Louisville, Kentucky, was awarded a grant to continue the responsibilities of Research Director.

Date Funded: 10/09

Dr. Shuo Lin, University of California, Los Angeles, in collaboration with Nadia Danilova, was awarded a grant for the project “Mechanism underlying erythroid deficiency in DBA using a zebrafish model.” The aims of this project are to further investigate the zebrafish model of DBA with an eye towards understanding the role played by p53 in DBA pathology. Understanding this pathway could lead to molecular targets for the development of new therapeutics for use in DBA.

Date Funded: 10/09

A grant for the project “Genotype/phenotype relationships in DBA” was awarded to Dr. Lydie Da Costa, Hôpital Robert Debré in Paris, France. Dr. Da Costa’s group has shown that different ribosomal protein mutations have distinct affects on the behaviour of cells derived from the marrow of DBA patients. These studies will provide insight into the clinical variability of DBA and perhaps ultimately lead to designer therapies.

Date Funded: 6/09

Dr. Johan Flygare of the Whitehead Institute of Biomedical Research, Cambridge, MA was awarded a grant for the project “Characterizing the mechanism of glucocorticoid treatment in DBA.” The goal of this project is to understand the mechanism of action by which glucocorticoids exert their positive effects in certain DBA patients. By understanding the mechanisms through which glucocorticoids work it may be possible to develop less toxic drugs that have similar or improved clinical benefits.

Date Funded: 5/09

The DBAF was a Bronze Level Sponsor of the 2009 International BioIron Society Conference where investigators from all over the world congregate to advance the fields related to iron metabolism.

Date Funded: 2/09

The DBAF co-sponsored the Tenth Annual Diamond Blackfan Anemia International Consensus Conference sponsored and organized by the Daniella Maria Arturi Foundation.